AOD-9604

AOD-9604 is a modified fragment of human growth hormone, specifically the C-terminal fragment corresponding to amino acids 176-191. The name stands for Anti-Obesity Drug 9604, reflecting the research focus that motivated its development. The fragment has been modified with the addition of a tyrosine residue at the N-terminus to stabilize the peptide for research purposes.

Researchers have studied AOD-9604 for its potential interactions with fat metabolism pathways independent of full growth hormone signaling. Studies have examined how AOD-9604 may stimulate lipolysis – the breakdown of stored triglycerides – and inhibit lipogenesis – the formation of new fat cells – in adipose tissue. Preclinical research has explored its effects on beta-3 adrenergic receptors, which play a role in fat cell activity.

Animal model studies have investigated AOD-9604’s effects on body composition, particularly in rodent models of diet-induced obesity. Researchers have noted that unlike full-length GH, AOD-9604 does not appear to significantly affect blood glucose levels or IGF-1 in preclinical studies, making it a useful research tool for isolating specific aspects of GH biology related to fat metabolism.

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