NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in all living cells, serving as a fundamental electron carrier in cellular energy metabolism. It participates in hundreds of redox reactions, cycling between its oxidized form (NAD+) and reduced form (NADH) to transfer electrons in glycolysis, the TCA cycle, and oxidative phosphorylation. Beyond energy metabolism, NAD+ is consumed as a substrate by several classes of signaling enzymes.
Researchers have studied NAD+ for its roles as a substrate for sirtuins (NAD+-dependent deacylases), PARPs (poly ADP-ribose polymerases involved in DNA repair), and CD38/CD157 (NAD+-consuming enzymes involved in calcium signaling). Studies have examined how NAD+ availability regulates sirtuin activity, which in turn modulates mitochondrial biogenesis, fatty acid oxidation, and stress response pathways through deacylation of target proteins. Research has explored how NAD+ levels decline with age and in various disease states.
Preclinical research has investigated NAD+ repletion strategies in aging models, exploring effects on metabolic function, mitochondrial respiration, and markers of cellular senescence. Studies in animal models have examined NAD+ supplementation effects on cognitive function, muscle health, and longevity parameters. Research has also explored its potential to modulate inflammatory pathways through PARP-1 activity and its role in DNA damage response and repair.
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