Ipamorelin is a synthetic pentapeptide growth hormone secretagogue with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. It acts as a selective agonist at the GHSR-1a (ghrelin receptor) and is distinguished by its high selectivity for GH release with minimal effects on cortisol, prolactin, and ACTH secretion. This selectivity profile has made it one of the most studied GH secretagogues in peptide research.
Researchers have examined Ipamorelin for its dose-dependent stimulation of GH release from pituitary somatotrophs. Studies have compared its selectivity profile to earlier GHRPs, noting that it produces robust GH release with significantly less impact on other pituitary hormones at equivalent doses. Research has examined the synergy between Ipamorelin and GHRH analogues such as CJC-1295 in amplifying GH pulsatility in animal models.
Preclinical research has explored Ipamorelin’s effects on body composition, bone mineral density, and muscle mass in animal aging models. Studies have also examined its influence on IGF-1 levels as a downstream marker of GH axis activity. Its favorable selectivity profile has made Ipamorelin a preferred research tool when studying GH secretagogue biology with minimal confounding effects from other hormone changes.
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